Karjakin beat Carlsen in a masterpiece. Yes, he did. What really happened was this: This time Carlsen gave up too much rope and Karjakin just played a perfect game. Such things will happen from time to time if you play with fire like Carlsen. It’s not a reason to panic, it’s just the downside of playing bad openings on purpose.
Nevertheless the game must have put Carlsen on tilt, because he basically went berserk against Mamedyarov. On the other hand the result shows that he could afford this “calculated risk” against this specific opponent. Shak is less of an machine than Sergey.
Play it safe!